Cardiovascular Diseases

small button blue GROUP LEADER | MAJOR INTERESTS | RESEARCH TEAM | CURRENT PROJECTS | RELEVANT PUBLICATIONS 

Cardiovascular diseases header

GROUP LEADER
João Paulo Venâncio | ORCID

 

MAJOR INTERESTS
We are investigating the pathophysiology of cardiovascular disease and also different forms of treatment and / or prevention such as therapeutic exercise. The relevance of this issue stems from epidemiological data that attribute to cardiovascular disease a leading cause of death and disability worldwide.

Specifically we aim at:

  • Technology measures applications in vascular diseases, including BPAM variation and IMCT variation with BPAM changes
  • General characterization of IMCT in Portuguese population
  • Genetic platelet polymorphisms and thrombotic risk
  • Genetic platelet polymorphisms and resistance to antiplatelet therapy
  • Angiology and vascular surgery
  • Exercise and cardiovascular diseases
  • Endothelial progenitors stem cells, platelet cells and exercise

 

RESEARCH TEAM

Researchers
António Almeida Dias | almeida.dias@ipsn.cespu.pt | 
António Braga | antonio.braga@ipsn.cespu.pt | 
João Paulo Venâncio | joao.venancio@ipsn.cespu.pt | ORCID
Maria Begoña Criado | mbegona.criado@ipsn.cespu.pt | ORCID
Maria do Céu Monteiro | mceu.monteiro@ipsn.cespu.pt | ORCID

PhD Students
Carlos Faria | carlos.faria@cespu.pt |
Luís Pina-Cabral | luis.cabral@ipsn.cespu.pt | 

 

CURRENT PROJECTS

Project dEfENCE-CESPU-2016: Acute effects of exercise on circulating levels of endothelial progenitor cells in patients with coronary artery disease. | PI: João Paulo Venâncio | Team: João Paulo Venâncio, Maria do Céu Monteiro, Fernando Ribeiro, Suiane Cavalcante | Funding Entity: CESPU | Period covered: 04-2016 to 03-2017

Coronary artery disease (CAD) is a dynamic and progressive pathological process of endothelial dysfunction and low-grade inflammation of the vascular wall. Endothelial Progenitor Cells (EPCs) are circulating endothelial precursor cells derived from bone marrow involved in angiogenesis and endothelial repair. Reduced number and functionality of the EPCs are associated with endothelial dysfunction and atherosclerosis, considered the underlying pathological profile of CAD. Physical exercise is able to mobilize EPCs into the bloodstream in healthy individuals; nonetheless in CAD patients the evidenced is scarce. We aim to determine the acute effect of PE in the mobilization of EPCs from bone marrow to circulation in patients with CAD, determining the mechanisms involved in this process. Thus, the circulating levels of EPCs and biomarkers potentially involve its mobilization will be determined before and after an exercise test maximal or limited by symptoms in 15 patients. This study will develop important clues to new measures of prevention and treatment involving the use of physical exercise in the CAD.

 

RELEVANT PUBLICATIONS

Huerta I, Barasoain M, Télez M, Longa M, Muga J, Barrenetxea G, Ortiz-Lastra E, González J, Criado B, Arrieta I

.2014

. Genotoxic evaluation of five Angiotesin II receptor blockers: in vivo and in vitro micronucleus assay. (Journal Article)

Mutat Res Genet Toxicol Environ Mutagen, 767 pp. 1–7.DOI: 10.1016/j.mrgentox.2014.04.005.

(BibTeX)

Ribeiro F, Ribeiro IP, Alves AJ, do Céu Monteiro M, Oliveira NL, Oliveira J, Amado F, Remião F, Duarte JA

.2013

. Effects of exercise training on endothelial progenitor cells in cardiovascular disease: a systematic review. (Journal Article)

Am J Phys Med Rehabil, 92 (11), pp. 1020–1030.DOI: 10.1097/PHM.0b013e31829b4c4f.

(BibTeX)

Pina-Cabral LB, Carvalhais V, Mesquita B, Escórcio C, Salgado P, Santos A, Ruivães E, Monteiro MC, Arrieta I, O'Connor E, Almeida-Dias A, Criado B

.2013

. Allelic and genotypic frequencies of platelet glycoprotein polymorphisms in a Portuguese population. (Journal Article)

Rev Port Cardiol, 32 (2), pp. 111–115.DOI: 10.1016/j.repc.2012.08.007.

(BibTeX)

Faria A, Costa D, Criado B, Albuquerque A, Escórcio C

.2013

. Left ventricular function influenced by MMP3 gene 5A/6A polymorphism (rs3025058): a gated-SPECT study (Journal Article)

Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization, 1 (2), pp. 89-99.DOI: 10.1080/21681163.2013.769748.

(BibTeX)

Faria A, Costa D, Criado B, Albuquerque A, Escórcio C

.2013

. Phenotypes of myocardial blood perfusion related to the genetic variations of metalloproteinases 3 (MMP3) and 9 (MMP9) (Journal Article)

Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization, 1 (3), pp. 119-129.DOI: 10.1080/21681163.2013.769749.

(BibTeX)

Criado M, Pina-Cabral L, Carvalhais V, Napoleão P, Pinheiro T, Mesquita B, Almeida-Dias A, Monteiro M

.2010

. Genetic variation in the Enos: Clinical implications. (Conference)

Pathophysiol Haemos Thromb, 37 pp. 369.DOI: 10.1159/000318096.

(BibTeX)

Criado M, Pina-Cabral L, Carvalhais V, Mesquita B, Santos A, Ruivães E, Monteiro M, Pereira C, Andrade C, Arrieta I, Almeida-Dias A

.2010

. Polymorphisms with relevant role in platelet function in Portuguese population (Conference)

European Journal of Human Genetics, 18 (1), pp. 262.Link: https://www.eshg.org/fileadmin/www.eshg.org/abstracts/ESHG2010Abstracts.pdf.

(BibTeX)

Pina-Cabral L, Santos L, Mesquita B, Amaro T, Magalhães S, Criado B

.2007

. Detection of survivin mRNA in urine of patients with superficial urothelial cell carcinomas. (Journal Article)

Clin Transl Oncol, 9 (11), pp. 731–736.

(BibTeX)

Teixeira J, Braga A, Fiúza C, Araújo R, Fonseca J, Cruz J, Santos J, Lencastre L, Teixeira A

.2007

. Gabinete de Coordenação de Colheitas de Orgãos e Transplantação do Hospital de São João: resultados de doze anos de actividade (Journal Article)

Arquivos Portugueses de Cirurgia, 16 (1-2-3-4), pp. 49-63.

(BibTeX)

Cruz JS, Teixeira JF, Costa HM, Braga AR

.1999

. False aneurysm of an axillary artery in an intravenous drug misuser. (Journal Article)

Eur J Surg, 165 (5), pp. 505–506.DOI: 10.1080/110241599750006794.

(BibTeX)